Ointments used to treat chancre include erythromycin ointment as well as ichthyosin ointment. Noma is a painful, ulcerative sexually transmitted disease that occurs in the patient’s genital organs and is mainly caused by infection with the bacterium Haemophilus ducreyi. It is not a difficult disease to treat, and most patients can be cured with active treatment, which is commonly used in the clinic as medication. If the patient’s condition is mild, erythromycin ointment, ichthyol ointment and other topical medicines can be used in the lesions as prescribed by the doctor, and if the lesions are ulcerated, hydrogen peroxide and potassium permanganate with low concentration should be used to clean and disinfect the lesions before the use of the above medicines. In addition to the above topical medications, patients with more serious conditions and swollen inguinal lymph nodes can be treated with azithromycin, erythromycin, or intramuscular injections of antibiotics such as ceftriaxone and macrolide. For patients with severe disease and poor drug treatment, they may need to seek medical attention and then be treated through noma excision surgery. In summary, drugs such as erythromycin ointment are effective in treating chancre, but they cannot be relied upon as a topical medication alone; patients still need to be treated orally, with injectable medications or even surgically if necessary. It is recommended that patients consult a doctor in a timely manner and choose the appropriate treatment according to their actual condition under the guidance of the doctor.