Lupus nephritis type IV usually cannot be completely cured, but with active treatment, the disease can be stabilized and the progression of renal function can be slowed down. Lupus nephritis type IV is a diffuse lupus nephritis (involving 50% of glomeruli), with extensive cell proliferation (endothelial and mesangial cells) and cellular infiltration, and extensive and severe nuclear fragmentation and crumpling. It can be divided into two subtypes, S: segmental lesions (involving <50% of glomerular capillary collaterals) and G: globular lesions (involving ≥50% of glomerular capillary collaterals). Thus, sore nephritis type IV is usually not completely curable, but induction and maintenance therapy with aggressive drug therapy, such as glucocorticoids and other immunosuppressive agents, is required in patients with active disease. Most patients can stabilize the active stage lesions and slow down the progression of renal function. Patients with lupus nephritis are advised to go to regular hospitals for timely consultation and targeted treatment or therapy under the guidance of doctors.