Espresso drinking in moderation is generally not harmful, but if a large number of frequent drinking can cause neurasthenia, osteoporosis, cardiovascular hazards. 1. neurasthenia: excessive drinking espresso can make the nervous system over-excited, causing insomnia, long-term drinking large quantities can cause irritability, anxiety, generalized depression, insomnia and memory loss. 2. Osteoporosis: excessive drinking of espresso, which caffeine can impede intestinal absorption of calcium ions, causing calcium loss, for menopausal women, a long time may cause osteoporosis. 3. Cardiovascular hazards: coffee contains caffeine, large amounts of drinking will cause abnormal excitement of the cardiovascular system, manifested as increased heart rate, for patients with underlying heart disease, large amounts of espresso, serious cases can induce myocardial infarction and other adverse consequences. Espresso can also cause stomach upset and other hazards, it is recommended to drink a moderate amount of coffee, in order to benefit the health of the body.