NSAIDs are a large class of non-hormonal drugs with antipyretic, analgesic and anti-inflammatory effects, represented by aspirin, indomethacin, ibuprofen, diclofenac, celecoxib and so on. Their “anti-inflammatory”, targeting non-bacterial inflammation, is different from the daily “inflammation and infection” caused by bacteria and viruses. Non-steroidal anti-inflammatory drugs through the inhibition of cyclooxygenase (is a key enzyme, able to arachidonic acid metabolites into prostaglandins and other inflammatory and pain-causing substances, thereby producing inflammation), so as to inhibit the production of prostaglandins and play an anti-inflammatory effect, after taking the adverse reactions: gastrointestinal reactions (including poor appetite, anorexia, abdominal pain, etc.), which is the most common, mainly because of the inhibition of the gastric mucosa protective effect of cyclooxygenase-1 Blocking cyclooxygenase-1 is an important factor in causing gastrointestinal side effects. In addition, the risk of cardiovascular disease, including myocardial infarction, stroke, etc. Therefore, for the elderly and patients with cardiovascular risk factors, risk assessment and monitoring should be done when using. For people with long-term heavy application, it is also important to note that there is a potential risk of kidney damage. Therefore blood and urine routine, liver and kidney function should be checked regularly before and after treatment, and attention should be paid to the presence of darkening of the stool. In order to reduce possible adverse reactions, the following attempts can be made: 1. In the application, the combination of two and more NSAIDs should be avoided. 2. In the presence of gastrointestinal discomfort or peptic ulcer, gastric mucosal protective agents or proton pump inhibitors can be added. Since the tolerance and efficacy response of each patient to different drugs are different, and the difference between individuals is great, therefore, it is necessary to choose suitable NSAIDs under the guidance of doctors in regular hospitals and according to the specific conditions of patients.