Penicillin-based medications can be given orally or intravenously for pus-filled wounds, but topical application is not effective, and the use of penicillin needs to ensure that the penicillin is not allergic to the situation. Be sure to confirm whether you have a history of allergy to penicillin, not sure need to do a skin test first, skin test results are negative before you can use. Penicillin and other drugs need to be metabolized by their own body enzymes to play the role of anti-infection, separate external use is basically ineffective. If the wound has pus, you can go to the hospital to find a surgeon to check, wound pus usually need to open the wound, remove the pus inside, and at the same time to remove the necrotic tissue, and then bandage the wound. Depending on the situation, antibiotics can be used orally or intravenously, and penicillin antibiotics or cephalosporin antibiotics can also be used, while penicillin should not be used on its own.