High anti-thyroid peroxidase antibody should be improved with relevant examinations to clarify the cause of the disease and treat the cause. High anti-thyroid peroxidase antibody may be related to Hashimoto’s thyroiditis and hyperthyroidism. It is recommended that the patient should go to the hospital in time. 1. Hashimoto’s thyroiditis: Thyroid peroxidase antibodies may be significantly elevated in blood tests. Hashimoto’s thyroiditis can be treated with drugs such as levothyroxine and glucocorticoids, and surgery if necessary. 2. Hyperthyroidism: high anti-thyroid peroxidase antibodies can also be seen. Treatment can use propylthiouracil, methylthiouracil, methimazole and other drugs. In severe cases, subtotal thyroidectomy may be performed. Treatment for high anti-thyroid peroxidase antibodies should be chosen according to the cause of the disease. If you need to use drugs, you need to use under the guidance of a doctor.