Blood transfusion between immediate family members is prone to transfusion-associated anti-host disease, which is more likely to occur the closer the blood relationship is between the donor and the person using the blood, so blood transfusion between immediate family members should be avoided as much as possible. When the immunoreactive cells in the white blood cells of the transfusion recipient enter the recipient’s body, due to the genetic similarity between the transfusion recipient and the transfusion recipient, if the immunoreactive cells are activated in the recipient’s body, it may cause damage to various organs of the recipient. Therefore, hospitals generally do not recommend blood transfusion for immediate family members to avoid adverse reactions caused by homologous antibodies. However, if blood transfusion between immediate family members is really necessary, if the blood type is the same and there are no relevant contraindications, the transfusion recipient’s blood source can be firstly removed from the leukocytes, and then safe blood transfusion can be carried out. Blood transfusion is recommended to be performed in a regular hospital under the supervision of a physician.