Taking fourteen days of triple therapy to review there is still H. pylori can use quadruple therapy that is, bismuth + proton pump inhibitor (such as omeprazole) + two antibiotics (such as amoxicillin + furazolidone), and change the lifestyle habits. Due to the rising trend of resistance of H. pylori to clarithromycin and metronidazole in recent years, H. pylori can become resistant to these antibiotics, and triple therapy has basically been abandoned. Those without contraindications to the use of bismuth can be changed to quadruple therapy, including bismuth (e.g., bismuth potassium citrate) + proton pump inhibitor (e.g., omeprazole) + two antibiotics (e.g., amoxicillin + furazolidone). The use of amoxicillin is subject to the presence of penicillin allergy, and the drugs should be used under medical supervision. The course of quadruple therapy is usually 14 days. For those who fail the first eradication, another one of the remaining treatment options can be chosen for remedial treatment. For those who are resistant to multiple antibiotics, drug sensitivity test can be done before treatment to choose sensitive antibiotics. Avoid eating pungent and irritating foods such as chili peppers and garlic during treatment. Pay attention to personal hygiene to avoid recurrent H. pylori infection.