The choice of treatment options for colorectal cancer liver metastases is a frequent clinical dilemma for surgeons and patients. The author briefly summarizes this difficult issue in the context of “Guidelines for the diagnosis and comprehensive treatment of colorectal cancer liver metastases (V2013)”, in order to provide reference for patients and their families. Liver is the main target organ of colorectal cancer hematogenous metastasis, and liver metastasis is one of the key points and difficulties in the treatment of colorectal cancer. 15%-25% of colorectal cancer patients have liver metastasis at the time of diagnosis, and another 15%-25% of patients will have liver metastasis after radical surgery of the primary colorectal cancer. The median survival of untreated patients with liver metastases is only 6.9 months, and the 5-year survival rate of patients with unresectable metastases is close to 0, while the median survival of patients with completely resected liver metastases is 35 months, and the 5-year survival rate can reach 30% to 50%. Therefore, colorectal cancer liver metastasis is not an incurable disease, and it may still achieve better results through standardized and systematic multidisciplinary treatment. Colorectal cancer liver metastasis treatment process