Itchy blisters on both sides of the heel are considered to be acute contact dermatitis, blistering athlete’s foot, excessive friction, etc., which can be treated with topical medication, oral medication, and enhanced care. 1. Acute contact dermatitis: After the skin comes into contact with some kind of exogenous material, an acute inflammatory reaction occurs in the part of the skin where the mucous membrane comes into contact with it, such as some kind of ingredient of the shoes and the dye of the socks, which causes pimples. You can apply local short-term light to medium-acting hormone cream (such as hydrocortisone cream, tretinoin cream), wear loose shoes and socks, reduce friction, stop activities, do not go to polluted environments to avoid infection. 2. Blistering tinea pedis: this is a fungal infection caused by dermatophytes, which will cause small blisters on the skin and is accompanied by itching symptoms, you can apply amorolfine, econazole and other medications, and if the effect of local medication is not obvious, you can take oral antifungal medications (e.g. terbinafine tablets, itraconazole tablets). 3. Excessive friction: If the shoes are not suitable or long walking, will cause friction on the heel area can also cause blisters, if the blisters are relatively small, it is recommended to strengthen the care is self-absorption, if the blisters are very large, it is recommended to go to the hospital dermatology department, by the medical staff in a sterile environment, with a sterile needle to draw out the liquid. Itchy blisters on both sides of the heel, there may be other reasons (such as eczema, pustular psoriasis, etc.), it is recommended to go to the hospital for a detailed examination, standardized treatment for the cause of the disease, the above drugs should be used in accordance with medical advice.