Urine protein 6 usually refers to urinary microalbumin, α₁microglobulin, β₂microglobulin, immunoglobulin G, urinary retinol-binding protein, urinary transferrin. Urine protein 6 can reflect the kidney condition, the significance of the examination is mainly to clarify whether the patient’s kidney function is abnormal. 1. urinary microalbumin: urinary microalbumin measurement reflects the early kidney injury, pathologically increased in diabetic nephropathy, hypertensive kidney damage. 2. α₁ microglobulin: it may suggest tubular reabsorption dysfunction, impaired glomerular filtration function, etc. Elevation is seen in renal insufficiency caused by various renal diseases, such as early glomerular injury, primary glomerulonephritis. 3. β₂ microglobulin: β2-microglobulin is very easy to pass through the glomerular filtration membrane, and almost all of it is reabsorbed and degraded by proximal tubular cells. It can provide a basis for identifying the nature of proteinuria, glomerular or tubular pathology, and the site of urinary tract infection. 4. Immunoglobulin G: Positive immunoglobulin G suggests non-selective proteinuria, which suggests more serious renal injury. 5. Urine retinol-binding protein: urine retinol-binding protein is more sensitive to early tubular damage, which can reflect the degree of early tubular damage. If it is elevated, it generally indicates that the tubular reabsorption capacity is reduced. 6. Urinary transferrin: Urinary transferrin is one of the indicators of early glomerular damage, mainly reflecting the impaired charge selection barrier of glomerular filtration membrane. It is recommended to go to the regular hospital for diagnosis and treatment to clarify the cause of abnormal urine protein six tests.