Cold application gel has no therapeutic effect on varicose veins in general, it can mainly play the role of symptomatic relief and cannot make varicose veins shrink. Clinically, if the varicose veins have pain, swelling and other uncomfortable symptoms, they can be relieved by applying cold gel. Varicose veins are caused by the stagnation of blood in the vein lumen and the weakness of the vein wall, which leads to the expansion and tortuosity of the blood vessels, resulting in the blood vessels protruding out of the skin, and the lower limbs may have a feeling of soreness and distension, and even hyperpigmentation, rash, flaking, etc. Minor varicose veins usually have no obvious symptoms, and do not need any special treatment. Wearing compression stockings under doctor’s advice can ease the discomfort. Severe varicose veins, which are characterized by significant swelling and pain, may develop hyperpigmentation of the skin, or even skin ulcers, must be treated in a timely manner, either surgically, such as modified surgery, which is a type of minimally invasive surgery, or with medications, such as Mazillin, Warfarin, and other medications. In case of varicose veins, it is recommended to visit the hospital and follow the doctor’s instructions.