Monkeypox is a zoonotic viral infectious disease caused by monkeypox virus infection, the clinical manifestations are mainly swollen lymph nodes, fever, rash and other symptoms. 1. Its incubation period is mostly 6-13 days. Early onset of moderate fever, mostly >38.5 ℃, can be accompanied by headache, drowsiness and other symptoms. A part of patients appear neck, axilla and other parts of the lymph node enlargement. 2. Rash appears about 2 days after the onset of the disease. Rash first on the face, and then spread to the limbs, mostly centrifugal distribution, hands and feet can appear rash, the number of rashes vary; can also involve the oral mucosa, genitals and cornea. Rash will go through several stages of change from macular rash, papule, herpes, pustule, can be accompanied by obvious itching and pain, about 2~4 weeks off. 3. Monkeypox is a self-limiting disease with a good prognosis in most cases. Severe cases are common in young children, immunosuppressed people, the prognosis is also related to the infected virus branch, the number of virus exposure, past health status. If you have a history of traveling to a monkeypox infected area or suspect that you have monkeypox, please go to the hospital as soon as possible to avoid delay.