Aging is a symptom of Hutchinson-Gilford Syndrome, also known as childhood progeria, a genetic disease first reported by Hutchinson in 1886. Progeria patients’ body aging process is 5 to 10 times faster than normal, the patient looks like an old man, the organs also quickly decline, resulting in a decline in physiological functions. Signs include thinness, hair loss and late teething. Children with this rare disease can look as if they are in their 60s or 70s, even though they are only 16 years old. Most of them die from diseases of aging, such as cardiovascular disease, for which there is no effective treatment, but only medication. Although the disease is a congenital disorder, it is not certain whether it is autosomal recessive or dominant. The disease is a syndrome characterized by delayed development and progressive age-related degenerative changes that occur in infancy. Laboratory tests: There are generally no abnormal changes, sometimes with increased serum cholesterol and abnormal lipoproteins, and serum glycerol and fatty acid levels are normal when checked 2h after a meal. Villee et al. suggested that the main abnormal changes in this disease are related to the impaired metabolism and synthesis of certain structural proteins such as collagen, actin, myoglobulin and keratin. Clinical laboratory tests: Hyaluronic acid values in the urine may be increased and lipid values in the blood are often abnormal. However, these tests are not very helpful for diagnosis. X-rays: Changes in the skull, thorax, long bones, and finger bones are observed at the age of 1 to 2 years, and there is also osteoporosis and a lack of soft tissue. Genetic mutation analysis: The Progeria Research Foundation has developed a “Diagnostic Testing Program” that can be used to find out if genetic changes or mutations have occurred.