There is no such concept as a cure for diffuse large b-cell lymphoma, but it can be called clinically cured if it does not recur for 5 years. Diffuse large b-cell lymphoma is a type of non-Hodgkin’s lymphoma and the most common lymphatic system tumor in adults, with common symptoms of painless, progressive lymph node enlargement and extranodal masses, often accompanied by fever and night sweats. Early-stage patients can achieve better therapeutic effect through immunochemotherapy and combined radiotherapy. If a patient survives for more than 5 years, he or she is said to be clinically cured. Some patients experience tumor recurrence within six months after the end of the entire chemotherapy, which is recurrence refractory and requires a second-line regimen of chemotherapy or hematopoietic stem cell transplantation, or can be cured. After the treatment of diffuse large b-cell lymphoma, one should change the bad living habits, pay attention to diet and hygiene, and have regular checkups in order to find out the recurrence status in time and control the disease.