The pathogenesis of hypertension varies according to the type, for example, the pathogenesis of primary hypertension is not clear, mostly related to genetic, environmental and other factors, while the pathogenesis of secondary hypertension is more clear, mostly related to renal parenchymal or renal vascular pathology, increased cortisol and so on. 1. Primary hypertension Genetic factors such as family history of hypertension, and/or environmental factors such as long-term high salt and high fat diet, obesity, smoking, etc. can lead to dysregulation of the nervous system, endothelial dysfunction, activation of the renin-angiotensin-aldosterone system, and impaired renal function, which can lead to an increase in blood pressure. 2. Secondary hypertension When renal parenchyma or renal vascular lesions, cortisol increase, tumors in neural ectoderm such as pheochromocytoma, will secrete a variety of factors that raise blood pressure, resulting in elevated blood pressure. In addition, in renal damage, excessive angiotensin II can also cause sodium retention through vasoconstriction, stimulation of aldosterone secretion, as well as increased sympathetic excitation, thus increasing blood pressure. In summary, hypertension may occur as a result of a combination of factors that are involved and combine in a variety of ways. Therefore, hypertension needs to be treated in accordance with medical advice and should not be self-medicated to avoid adverse consequences.