Joint pain in the limbs, the body has no energy, mostly refers to joint pain in the limbs, fatigue, the common causes are fatigue, osteoporosis, rheumatoid arthritis, osteoarthritis and so on. 1. Exhaustion: after strenuous exercise, long hours of physical labor, the body is overworked, the accumulation of lactic acid in the muscles, the joints have a transient synovial edema, thus appearing joint pain in the limbs, the weakness of the performance of the joints, you can take appropriate rest. 2. Osteoporosis: Osteoporosis is caused by old age, calcium deficiency, long-term use of hormones, etc. It will also cause pain and weakness in the joints of the limbs, and it is easy to fracture. 3. Rheumatoid arthritis: it is an autoimmune disease, due to the immune cells attacking the normal tissues of the joints of the limbs, resulting in joint damage, and also symptoms such as pain and weakness in the joints of the limbs. 4. Osteoarthritis: because of prolonged physical labor, advanced age, obesity and other reasons, resulting in systemic osteoarthritis, joint cartilage degeneration, osteophytes, can appear in the joints of the limbs, pain, fatigue, difficulty in activities and other symptoms. Causes of limb joint pain, fatigue more reasons, but also may be related to infection, malignant tumors, systemic lupus erythematosus and other diseases, if the symptoms continue to be unrelieved, it is recommended to consult a doctor in time to clarify the cause of the disease, targeted treatment.