There is no such thing as “the best way to take pioglitazone hydrochloride”, the way to take pioglitazone hydrochloride follows the principle of individualization, and should be used according to the doctor’s instructions. The recommended use of pioglitazone hydrochloride is once a day by mouth. Adverse effects of pioglitazone hydrochloride include anemia, mild to moderate edema, hypoglycemic reactions, abnormal liver function, macular edema, lipid changes, and fractures. Note that the drug is contraindicated in people who are allergic to the product, have a history of bladder cancer, or have unexplained hematuria of the naked eye. If the patient develops symptoms of hypoglycemia when this product is used in combination with an insulin secretion enhancer (e.g. glimepiride), the dose of the insulin secretion enhancer should be reduced. Pioglitazone hydrochloride needs to be regulated under professional medical supervision.