Low resistance to chemotherapy for acute lymphatic leukemia is often accompanied by infections and other complications, and active and effective preventive and therapeutic measures should be taken before and at the same time as chemotherapy in order to ensure the smooth progress of chemotherapy. 1. Low resistance after chemotherapy for acute lymphoblastic leukemia, patients may develop infections and other diseases, which are the most common complications before and after induction chemotherapy. The onset of the disease is accompanied by a lack of granulocytes, coupled with the patient’s own low immune function and mucosal barrier damage after chemotherapy, prone to a variety of serious infections. Respiratory tract infection is the most common. 2. Bleeding and leukocytolysis syndrome are also complications that often occur in chemotherapy for acute leukemia. (1) Bleeding: those who are using menthylase during chemotherapy are prone to hypofibrinogenemia. (2) Leukocytolysis syndrome: for those with high leukocyte counts (leukocytes greater than 100×10^9/L), the massive destruction of leukemia cells after chemotherapy is likely to lead to leukocytolysis syndrome, with complications such as DIC, hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia. Acute lymphatic leukemia chemotherapy low resistance may also have other complications, it is recommended that the diagnosis of acute lymphatic leukemia after the timely standardized treatment.