The fast-acting drugs for duodenal ulcer include acid-suppressing drugs and gastric mucosa-protecting drugs. 1. Acid-suppressing drugs: with the effect of inhibiting the secretion of gastric acid, they are divided into Hâ‚‚-receptor antagonists (such as ranitidine) and proton pump inhibitors (such as omeprazole). 2. Gastric mucosal protective agents: can neutralize gastric acid or directly cover the ulcer surface, there are magnesium aluminum carbonate, aluminum thioglycollate, aluminum phosphate, colloidal bismuth pectin and so on. 3. Patients with combined Helicobacter pylori infection without contraindications can be treated with quadruple therapy eradication, i.e., proton pump inhibitor plus bismuth and two antibiotics for treatment, such as amoxicillin and metronidazole. However, it should be noted that the appropriate drugs must be selected under the guidance of the doctor, and not blindly abuse the drugs.