The advantages of amlodipine are rapid onset of action, etc., the disadvantage is the complication of sympathetic symptoms; Benadryl is characterized by the improvement of proteinuria, etc., the disadvantage is the irritation of dry cough. Amlodipine is a calcium channel antagonist, the advantages are fast onset of action, small individual variability, small effect on the patient’s blood glucose, blood lipids, the effect on the elderly is better, but also can improve the hypertension of alcohol drinkers. Side effects are complications of sympathetic excitation symptoms, such as increased heart rate, flushing, headache and other manifestations. Benazepril is an angiotensin II-converting enzyme inhibitor with the advantage of improving insulin resistance and reducing urinary protein, and is more effective in hypertensive patients with obesity, diabetes, and damage to target organs such as the heart and kidneys. Side effects are irritating dry cough and angioedema. Amlodipine and Benadryl should be used properly under the supervision of a clinician.