Fever at night during shingles treatment is usually caused by fluctuations in the condition during the treatment of the disease and is also associated with secondary bacterial infections. Herpes zoster is generally a skin disease caused by varicella-zoster virus infection, and fluctuations of the disease, such as worsening of lesions accompanied by fever, may occur during treatment. If shingles is not treated effectively and in a timely manner, failure to protect the skin after the blisters break may induce a bacterial infection, which can also lead to fever. The fever may be more pronounced at night when the vagus nerve is excited. Fever at night during the treatment of shingles is recommended to consult a doctor in time, under the guidance of a physician to carry out relevant treatment.