The clinical above says three plus urine protein, but normal kidney function, mild disease can be cured. To know the relationship between massive proteinuria and kidney function, massive proteinuria usually occurs in nephrotic syndrome. Nephrotic syndrome can cause hypoproteinemia, secondary to sunken edema, in addition to the obvious effects of long-term leakage of large amounts of proteinuria on kidney function, the proliferation of cells in the thylakoid area, the increase in the stroma, over time will cause glomerulosclerosis, but this process is progressive, sometimes a slow-onset process. When the kidney function has problems, the human body will also have compensated, so many people in the compensated stage of kidney function, the clinical above does not necessarily show water-electrolyte disorders, or sometimes accompanied by hematuria this situation. If a large amount of proteinuria is not controlled, the final trend will cause renal insufficiency, in which case the glomerulus is sclerotic, the renal function cannot be compensated, and the clinical manifestation of renal insufficiency will appear. Some kidney function does not respond clinically to large amounts of proteinuria, but in fact the kidneys have been damaged.