There are many causes of spleen atrophy, the main causes are hematologic diseases and cardiovascular diseases. 1. Blood system diseases: Blood system diseases can also cause spleen atrophy, such as sickle cell anemia and other diseases, which is due to the change in the shape of blood cells leading to blood cell lysis, and the spleen is an important organ for blood supply, which is dysfunctional, thus causing atrophy. 2. Cardiovascular diseases: If you suffer from cardiovascular diseases such as pulmonary embolism, heart valve disease and heart failure, the blood supply to the spleen will be insufficient due to the obstruction of local circulation, resulting in symptoms of spleen atrophy. In addition, hyperthyroidism and gastrointestinal dysfunction can also lead to spleen atrophy. If the phenomenon of spleen atrophy is found during the examination, patients are advised to go to the hospital in time for further examination to find out the cause of the disease and undergo professional treatment according to their own conditions under the guidance of doctors.