The annual rabies vaccination may cause harm to the body; the harm to the body lies in the adverse reactions of rabies vaccine; the adverse reactions of rabies vaccine include common adverse reactions and rare adverse reactions. 1. Common adverse reactions: pain and itching at the injection site within 24 hours after vaccination; systemic reactions such as fever, weakness, headache, dizziness, muscle pain, joint pain, vomiting and abdominal pain. 2. Rare adverse reactions: e.g. allergic rash, anaphylaxis, anaphylactic purpura, etc. Five shots of rabies vaccine per year may be the reason for annual bites and scratches by cats, dogs and other animals, rabies exposure or high-risk groups need to be vaccinated in a timely manner, and the general population really should not be vaccinated with five shots every year. Injection of this vaccine should be equipped with drugs such as epinephrine for first aid in case of severe allergic reactions; to prevent rabies, avoid being bitten by dogs, try not to get five shots of rabies vaccine every year, to avoid harm to the body because of vaccination.