Vocal cord leukoplakia has no significant effect on voice changes after surgery. Vocal cord leukoplakia is an abnormal lesion of the vocal cords caused by prolonged improper use of voice, smoking, drinking, shouting, and exertion. Clinically, vocal cord leukoplakia is a pre-cancerous lesion, and the patient will have hoarseness, which is continuously aggravated. Laryngoscopy can reveal a pale white patchy neoplasm in the anterior middle third of the vocal folds or the entire vocal folds, which can cause incomplete closure of the vocal folds and lead to hoarseness. Local pathology needs to be taken, and if the diagnosis is confirmed as vocal cord leukoplakia, the procedure can be performed with supported laryngoscopic vocal cord leukoplakia removal, which is a minimally invasive procedure that removes as much diseased tissue as possible, but does not destroy the muscles. Therefore, the hoarseness of the patient’s voice will not be greatly affected after the operation, but also requires regular post-operative review, and once signs of recurrence are detected, surgery needs to be performed as soon as possible.