Hepatitis B vaccine three months and hard lumps may be due to its own factors, infection and vaccine stimulation of the human body, etc., the specific situation is analyzed as follows.1, its own factors: usually the vaccine injection site needs to be selected, but if the selection of the time ignored the injection location itself has local skin hyperplasia or subcutaneous space-occupying lesions, then the patients with hepatitis B vaccine for three months, this nodule will still exist. There may be skin hyperplasia, sebaceous cysts, fibromas, lipomas, etc. At this time, ultrasonography can be carried out to clarify the diagnosis, and surgical excision can be carried out for such cases. This situation is not the impact of the vaccine, patients do not have to worry; 2, infection: due to the patient’s low immunity or vaccination disinfection is not standardized, local foreign body retention may cause infection of the injection site, may be an acute attack will be slow delayed onset, mainly associated with the patient’s physical condition. Therefore, three months after the hepatitis B vaccine and hard lumps need to consider the possibility of chronic infection, the patient’s local skin will generally be accompanied by obvious redness, swelling, tenderness and so on. At this time, it is recommended that patients will be local alcohol disinfection, erythromycin ointment external coating, with the use of cephalosporin antibiotics to improve the formation of abscesses in some patients can also be surgical incision and drainage; 3, vaccine stimulation of the human body: normal hepatitis B vaccine contains auxiliary components, such as aluminum hydroxide, some patients may be more sensitive to it, slow absorption after injection, the local hardness will be produced and may be accompanied by a certain pain, usually may be accompanied by Some patients may be more sensitive to it, and it will be absorbed slowly after injection, resulting in hard lumps locally, which may be accompanied by certain pain. Usually, it may be absorbed in about one month, and individual patients may extend it to about three months. At this time, you can continue to observe, usually can be relieved naturally, patients should be careful not to stimulate the local hard lump, waiting for slow recovery. Some patients will be infected, pus and so on, usually need to carry out cephalosporin antibiotic anti-infection treatment, or even local incision and drainage. At this time for the local hard lumps need to go to the hospital for ultrasound examination, local can use hot compresses and so on to promote recovery.