Strong lymph node reaction caused by BCG vaccination mostly occurs 6 months after vaccination. In general, newborns have no innate immunodeficiency, good development, lesions are limited, at this time, the lesions are mild, hot compresses can be effective. If the ultrasound has shown calcification in the nodule, indicating that the cold abscess has been formed, at this time with the needle suction method to suck out the pus, the pus for bacterial culture and tuberculosis mycobacteria examination, if necessary, the nodule injection of isoniazid, can promote the death of bacillus Calmette-Guérin. For those who have pus, it should be emphasized that the wound needs to be thoroughly debrided at each dressing change, and at the same time the wound should be drained with built-in drainage strips, aiming at killing the residual bacteria in the lesion with locally high concentration of drugs, which is conducive to the healing of the wound as soon as possible. Local treatment, children’s pain is small, less cost, but for more serious lesions, inflammation is more extensive, the wound is larger and deeper, the wound is not healed for a long time, if necessary, can be added to the oral anti-tuberculosis drug treatment.