Many patients with thin endometrium will ask, does thin endometrium affect pregnancy? In fact, if we compare the fertilized egg to the seed of life, then the endometrium is the soil that nurtures the seed. If the thickness of the lining of the uterus is not enough, it is like the land is not fertile enough to provide sufficient conditions for the fertilization of the egg and growth and development, thus affecting the fertility of women. So, let’s learn more about endometrial thickness today! How thick is the endometrium? Generally, the thickness of normal endometrium varies from 5-10MM, and the thickness of endometrium varies in different periods: the endometrium in proliferative stage is about 9-10mm, the thickness of endometrium in secretory stage is about 5-6mm, and the thickness of endometrium in menstruation stage can be up to 8-10mm.The thickness of endometrium changes with the cycle of the ovaries, and the endometrium is in the proliferative stage from the 5th day of menstrual cycle. The endometrium is in the proliferative phase from the 5th day of the menstrual cycle, and the endometrium keeps on thickening until the 14th day of menstruation, when it can be thickened to 3-4mm; in the second half of the menstrual cycle, the endometrium is in the secretory phase, but it still continues to thicken, and the endometrium can be up to 10mm thick by the time of menstruation.In normal circumstances, the thickness of the endometrium of a female is 8-12mm, and the minimum thickness should not be lower than 6mm. Generally speaking, the thickness of the uterine lining is around 10mm after a new pregnancy. According to experts, the thickness of the uterine lining that facilitates conception is about 8 mm. The best time to have a fertile lining is during the luteal phase. Why does the lining thicken? Reason 1: endogenous estrogen (1) non-ovulation: in pubertal girls, perimenopausal women, hypothalamus-pituitary-ovarian axis of a certain part of the dysfunction, polycystic ovary syndrome, etc., there can be a phenomenon of non-ovulation, so that the endometrium for a longer period of time continuously subject to the action of estrogen, no progesterone counteracting the lack of cyclic secretion period of the transformation of the long-term in the proliferation of state. 40 years of age patients with atypical hyperplasia of endometrium, in addition to its endometrium has the effect of estrogen, no progesterone counteracting the lack of cycle secretion period of transformation of the state. In patients with atypical hyperplasia under 40 years of age, in addition to focal atypical hyperplasia, more than 80% of the endometrium has no secretory phase; 70% of the basal body temperature measurement results are monophasic. Therefore, most patients do not ovulate. (2) Obesity: in obese women, androstenedione secreted by the adrenal gland, through the role of aromatase in the adipose tissue is converted to estrone; the more adipose tissue, the stronger the conversion ability, the higher the plasma estrone level, thus causing persistent estrogenic effects. (3) Endocrine functional tumors: endocrine functional tumors are rare tumors, but 7.5% of them are endocrine functional tumors in research statistics. Gonadotropic dysfunction of pituitary gland and ovarian granulosa cell tumor are also persistent estrogen secreting tumors. Cause 2: Exogenous estrogen (1) Estrogen replacement therapy (ERT): In peri-menopausal or post-menopausal period, there are menopausal syndromes due to the lack of estrogen, and at the same time, there may be osteoporosis, abnormalities in lipid metabolism, cardiovascular changes, and even changes in the activity of brain cells, etc. Therefore, ERT is gradually and widely used. Therefore, ERT has gradually been widely used and has achieved very good results. However, ERT with estrogen alone will stimulate endometrial hyperplasia. If estrogen alone is used for one year, endometrial hyperplasia can be seen in 20% of women (Woodruff 1994), and ERT is often used for years and years, or even for the rest of one’s life. In the long run, if progesterone is not used at the same time, serious endometrial hyperplasia, or even endometrial cancer, will occur. (2) Application of Tamoxifen: Tamoxifen (Tamoxifen TAM) has the effect of anti-estrogen, so it is used in postmenopausal advanced breast cancer patients. Under the condition of low estrogen, TAM also has a weak estrogen-like effect, so long-term use of TAM, can also make the endometrium hyperplasia. The treatment of atypical endometrial hyperplasia, first of all, we need to clarify the diagnosis, find out the cause of atypical hyperplasia, whether there are polycystic ovaries, functional ovarian tumors or other endocrine dysfunction and so on. Anyone with any of the above conditions should be given targeted treatment. At the same time, symptomatic treatment of endometrial atypical hyperplasia can be initiated with medication or surgery. The choice of these two treatment options should be based on age, type of endometrial hyperplasia, fertility requirements and so on. Too thin endometrium leads to infertility The thickness of the endometrium varies at different times of a woman’s menstrual cycle, mainly due to the influence of hormone secretion at different times. If the endometrial lining is thin due to factors such as miscarriage, it will have a great impact on a woman’s pregnancy. There are many reasons for the thinning of the uterine lining, the most common reasons are: 1. Endocrine disorders: women’s emotions have a great impact on the uterine lining, long-term nervousness and worry often lead to endocrine disorders, which affects the thickness of the lining. 2. 2. Abortion and scraping damage to the lining: the lining is divided into three layers, the top layer is peeled off every month, the middle layer and the bottom layer is not peeled off, if the middle layer is damaged, the impact is not too big, if the bottom layer is damaged, then the consequences will be more serious. 3. endometrial lesions: such as endometrial polyps, endometrial cancer and so on. Thin endometrial lining can make it difficult for the fertilized egg to attach to the uterus, thus leading to infertility.