The criterion for massive proteinuria is a 24-hour urine protein level greater than 3.5 g/d. When the urine protein is more than 150mg/d and the urine protein is qualitatively positive, it is called proteinuria. If the amount of urine protein is >3.5g/d, it is called massive proteinuria. Proteinuria can be divided into physiologic proteinuria and pathologic proteinuria according to its nature. Physiological proteinuria is more common in the case of strenuous exercise, fever, etc., the patient’s kidneys are not organic lesions, no special treatment is needed, and the urine protein can usually turn negative after rest. Pathologic proteinuria can be caused by a number of disease factors, such as primary glomerular disease, lupus nephritis, diabetic nephropathy, dry syndrome, tubulointerstitial disease and so on. Massive proteinuria is usually caused by damage to the glomerular basement membrane and massive loss of protein into the urine, and a large amount of foam can be seen in the urine. When the patient has a large amount of proteinuria, it is recommended to go to the regular hospital in time, improve the examination to clarify the cause of the disease, and then give targeted treatment or treatment under the guidance of the doctor.