In general, fertility preservation in early pregnancy will not affect the results of Down’s syndrome screening. When Down’s syndrome screening is performed around 14-20 weeks of pregnancy, the levels of alpha-fetoprotein, free estriol and chorionic gonadotropin in the blood of the pregnant woman will be measured and the risk of congenital chromosomal abnormalities such as trisomy 21 will be assessed taking into account the woman’s age, week of gestation, body weight and expected date of delivery. If a pregnant woman has a preeclampsia in early pregnancy, she should consult a doctor in time and take or inject progesterone as prescribed by the doctor to preserve the fetus. In addition to this, the pregnant woman should also reduce her activities and try to stay in bed as much as possible, and the doctor may also advise the patient to take some proprietary Chinese medicines to help preserve the fetus. However, these measures do not usually interfere with the results of the Down’s syndrome test. If the results of the Down’s syndrome test are abnormal, the pregnant woman will need to undergo a non-invasive DNA test or amniocentesis to test the chromosomal status of the fetus, in order to determine whether there is any chromosomal abnormality in the fetus, and based on the results of the test, decide whether intervention or treatment is needed.