The treatment of gastric sinus combined with duodenal bulbitis mainly includes eradication of Helicobacter pylori, protection of gastric mucosa, promotion of gastric motility, acid suppression, etc. The commonly used drugs are omeprazole, bismuth potassium citrate, aluminum thioglycollate, domperidone and so on. Those with H. pylori infection first need to eradicate H. pylori and standardize the quadruple combination of drugs, i.e., 2 antibiotics such as amoxicillin and clarithromycin + bismuth + proton pump inhibitor such as omeprazole in combination. When there are obvious symptoms such as bloating and early satiety, prokinetic drugs such as mosapride can be used symptomatically; for those with acid reflux and heartburn symptoms, acid inhibitors such as omeprazole, pantoprazole and ranitidine can be applied. Biologically active drugs such as folic acid, vitamin C and vitamin E can also be supplemented. Do not take medication without authorization, you need to use medication under the guidance of a doctor.