Coagulative necrosis is a lesion in which protein degeneration and necrosis are the main pathology, and the disease occurs in the heart muscle and internal organs such as the liver, spleen, and kidney. The main causative factors are due to ischemia, intoxication, chemical drug stimulation, etc. The specific pathogenesis is not clear. The clinical manifestations vary depending on the site of onset. If the disease occurs in the myocardium, it may lead to heart failure, with common symptoms such as chest tightness, heartburn, and in severe cases, life-threatening cardiac arrest. If the disease occurs in the liver, liver function damage is the main manifestation, mainly the increase of transaminases, patients have pain in the liver area, loss of appetite, etc. In the kidney, hematuria and proteinuria may be manifested, and in severe cases, renal failure may occur. If it occurs in the spleen, it may lead to elevated platelets, immune deficiency, pain and discomfort in the left upper abdomen, etc.