Different patients have different physique, different responsiveness to treatment and different severity of the disease, so there is no optimal treatment plan for undifferentiated thyroid cancer, which is mainly treated by surgery at present. The prognosis of undifferentiated thyroid cancer is relatively poor, and once detected, patients need to undergo radical surgical treatment as soon as possible. If the patient has lost the best opportunity for surgery, local radiotherapy (iodine 131, etc.) is the main treatment, and systemic chemotherapy can also be administered under the guidance of doctors to slow down the development of the disease. Chemotherapy (commonly used ones are cisplatin, adriamycin, vincristine, etc.) can effectively control the condition of thyroid cancer after surgery, and radiotherapy can prevent the disease from further development and recurrence. Patients with undifferentiated thyroid cancer should actively cooperate with doctors. After surgical treatment, they should follow the doctor’s instructions for regular review and treatment.