Women diagnosed with endometrial cancer should not be overly concerned because endometrial cancer is usually detected early and can be treated well with surgery (removal of the uterus, bilateral fallopian tubes, ovaries and potentially metastatic lymph nodes) or radiation therapy. For some patients, drug treatment is also possible without surgery. The main treatment methods for endometrial cancer are surgery, radiotherapy, chemotherapy and progesterone therapy. 1.Surgery Some gynecologic oncologists believe that the rate of pelvic lymph node metastasis is not high in early endometrial cancer, especially in highly differentiated endometrioid carcinoma whose lesions are limited to the endometrium or whose infiltration depth does not exceed 1/2 of the muscular layer. Lymph node dissection, which carries certain complications and surgical risks for all patients, is not cost effective in terms of health economics. A study from Mayo Medical Center, a leading U.S. hospital, showed that total hysterectomy and bilateral salpingo-oophorectomy are adequate surgical treatments for certain eligible patients with endometrial cancer. These conditions, known as the Mayo low-risk endometrial cancer criteria, include: endometrioid carcinoma, highly differentiated, tumor less than 2 cm in diameter, and infiltration of no more than 1/2 of the myometrium. Some hospitals and some doctors in China use Mayo’s criteria. In fact, it can be considered that because of the better prognosis of endometrial cancer, the 5-year survival rate of early stage patients are above 90%, and the survival rate of patients with or without removal of pelvic lymph nodes and para-abdominal aortic lymph nodes has little difference. 2.Radiotherapy Not all endometrial cancers are suitable for surgery. For patients with advanced endometrial cancer, extreme obesity or multiple medical diseases that are not suitable for surgery, radiation therapy can be used. For patients who are found to have high risk factors for recurrence after surgery, they also need adjuvant radiotherapy. The determination of these factors is more complicated and needs to be decided by professional doctors. 3.Chemotherapy For type II endometrial cancer (endometrial plasmacytoid papillary carcinoma and clear cell carcinoma, etc.), the treatment principle is based on the standard of ovarian cancer, that is, adjuvant chemotherapy based on comprehensive tumor cell reduction (removal of the uterus and bilateral fallopian ovaries, pelvic and para-abdominal aortic lymph nodes, in addition to removal of the greater omentum and appendix). For advanced and recurrent endometrial cancer, chemotherapy can also be used for salvage treatment if radiotherapy and surgery cannot be performed. 4.Endocrine therapy For some young and infertile endometrial cancer patients or patients with endometrial cancer after surgery and radiotherapy, endocrine therapy with progesterone can be used.