Pulmonary pemphigoid is an irreversible disease for which there is no effective drug treatment. However, smoking cessation can slow the progression and reduce the incidence of complications such as infections and emphysema. Inflammatory lesions in the small bronchial tubes, including tuberculosis, emphysema, and pneumonia, are common causes of pulmonary blisters. When inflammatory lesions occur in the small bronchial tubes, the airways become narrowed and edematous, or even lead to blockage of the lumen, causing gas to accumulate in the alveoli and leading to the occurrence of pulmonary blisters. The smoke produced by burning tobacco contains a variety of harmful substances that can damage the structure and function of the airways, so smoking can damage the airways and increase the chances of infection, thus aggravating the symptoms of pulmonary pustules. Smoking and the stimulation of physical and chemical factors can cause the destruction of alveolar structure is also the cause of pulmonary pustules. After quitting smoking, removing the triggers can slow down the progress, which can reduce the damage to the airways and improve the quality of life of patients with pulmonary pustules. If there is physical discomfort, please consult a doctor in time, and patients are advised to actively quit smoking.