Herpes simplex virus type 2 positivity is caused by infection with the herpes simplex virus type 2, which is transmitted by direct or sexual contact, and the virus can be transmitted through broken skin, mucous membranes, and mainly through sexual contact. Herpes simplex virus (HSV) is a double-stranded DNA virus, which can be categorized into two types according to the antigenicity of the viral proteins, i.e. herpes simplex virus type 1 and herpes simplex virus type 2. Of these, herpes simplex virus type 2 is prevalent in adults and is mainly transmitted through close sexual contact, with most of the damage occurring in the genital area. Humans are the only natural hosts of HSV, and herpes simplex virus type 2 can be found in the blisters and genital secretions of infected people. It is recommended that patients seek timely medical attention and symptomatic treatment under the guidance of a doctor, internal or external antiviral drugs, commonly used drugs such as acyclovir, vasiclovir and so on. The drugs should be used in accordance with the doctor’s instructions, do not self-medication.