There are two main types of drugs to reduce atrial aqueous production, one is β-adrenergic receptor blockers and the other is carbonic anhydrase inhibitors. β-adrenergic receptor blockers commonly used are 0.5% timolol eye drops, 0.5% betadine, betasol eye drops, 1-2 drops per day, which reduce IOP by inhibiting atrial aqueous production, without affecting pupil size and regulation function, but their magnitude of IOP reduction is limited. However, the magnitude of IOP reduction is limited, and the effect of IOP reduction decreases after long-term application. The other category is carbonic anhydrase inhibitors, including topical drops of brinzolamide eye drops, which also reduce atrial aqueous production, with side effects such as mild discomfort in the eyes, abnormal taste, and bitterness in the mouth. Systemic oral carbonic anhydrase inhibitors, such as acetazolamide, can also be used, but with kidney stones, sulfonamide allergy to be prohibited, the common side effects are fatigue, nausea, abnormal sensation, electrolyte disorders, urinary tract stones, personality changes, etc.