Differential diagnosis of hemolytic anemia includes acute hemorrhagic anemia, nutritional anemia, hemorrhage in tissues or body cavities, anemia with ineffective hematopoiesis of the bone marrow, familial non-hemolytic jaundice, and metastatic carcinoma of the bone marrow. 1. Acute hemorrhagic anemia: bleeding foci are not clear and reticulocytes are increased. 2. Nutritional anemia: iron supplementation, vitamin B, or folic acid treatment is effective in the early stage, when hemoglobin has not been restored but reticulocytes are increased. 3. Tissue or intracorporeal hemorrhage: this can lead to increased unconjugated bilirubin. 4. Anemia with ineffective hematopoiesis of the bone marrow: the presence of juvenile red blood cells in the peripheral blood and a significant proliferation of juvenile red blood cells in the bone marrow. 5. Familial non-hemolytic jaundice: there is a prolonged or intermittent increase in unconjugated bilirubin. 6. Metastatic carcinoma of the bone marrow: anemia of young granulocytes and erythrocytes in the peripheral blood.