Blood creatinine 116μmol/L and urine protein negative are the results of routine blood and urine tests. It may be caused by physiological factors, nephritis, nephrotic syndrome, diabetic nephropathy, etc. It can be treated by improving lifestyle and medication. 1. Physiological factors: creatinine 116μmol/L may be caused by short-term eating a large amount of meat, strenuous exercise and other physiological factors, at this time after adjusting the lifestyle can generally be improved. 2. Nephritis: 116μmol/L creatinine and negative urine protein caused by nephritis, according to different etiology, commonly used drugs are angiotensin-converting enzyme inhibitors/angiotensin II receptor antagonists (such as enalapril, valsartan), anti-infective drugs (such as amoxicillin, etc.), and diuretics (such as furosemide, etc.). 3. Nephrotic syndrome: Nephrotic syndrome can also lead to the phenomenon of 116 μmol/L creatinine and negative urine protein, patients can take oral prednisone acetate tablets, methylprednisolone and other glucocorticosteroids as prescribed by the doctor, as well as cyclophosphamide tablets, tacrolimus and other cytotoxic drugs. 4. Diabetic nephropathy: diabetic nephropathy can also lead to the phenomenon of blood creatinine 116 μmol / L, negative urine protein, the patient can follow the doctor’s instructions to take oral akaposan tablets, Repaglinide tablets and other hypoglycemic drugs. Routine blood and urine test results for blood creatinine 116μmol / L, urine protein negative, may also be hypertensive nephropathy, lupus nephropathy and other diseases, it is recommended that you should consult a doctor in a timely manner, in accordance with the doctor’s instructions for standardized treatment, do not use their own medication.