Breath-holding is a type of dyspnea. If you always feel breath-holding, you need to consider the following problems: firstly, respiratory diseases, such as allergic rhinitis, allergic pharyngitis, variant cough, bronchial asthma, which are mainly sensitive to changes in outside air and can lead to breath-holding. Next, we should pay attention to cardiovascular diseases, such as myocardial ischemia, arrhythmia, angina pectoris, and myocardial infarction, which are mostly seen in the elderly and require further electrocardiogram, cardiac ultrasound, coronary CT, and coronary angiography. It is also important to note that breath-holding is seen in digestive system diseases, such as reflux esophagitis, gastroesophageal reflux disease, gastric acid hypersecretion, chronic erosive gastritis, and biliary gastritis caused by gallstones. Breath-holding is mainly seen in 3 diseases of the respiratory, cardiovascular, and digestive systems, and can be examined clinically according to the patient’s specific symptoms.