Patients with rosacea or facial acne may present with blepharo-keratoconjunctivitis, a conjunctival congestion with conjunctival vasodilatation similar to the capillary dilatation of the nose and face, and keratoconjunctivitis, which primarily affects the blepharosphene and is often located near the corneal limbus. It begins with punctate corneal epitheliitis, followed by stromal scarring, thinning and neovascularization. The corneal lesions are intermittent, with multiple recurrent corneal stromal infiltrations with shallow ulcers that progress toward the center of the cornea. Eventually only the upper cornea is uninvolved. It may also present primarily as corneal thinning and lead to posterior elastic lamina bulging or even corneal perforation. Oral tetracyclines can control the inflammation of the skin and eye, blepharitis is obvious in the eyes of the local clean care, lid massage is very important, the eye should be applied topically under the guidance of the doctor corticosteroid hormones and artificial tears can be effective in controlling the active inflammation and improve the health of the ocular surface.