If methylprednisolone is applied irregularly, it will often cause the following hazards. 1. First, it can cause hypertension in children, because methylprednisolone is a glucocorticoid, which can cause water and sodium retention in children, thus causing an increase in blood pressure, especially if methylprednisolone is applied in large quantities for a long time. 2. In addition, it can cause hypocalcemia in children because methylprednisolone can cause calcium loss in children, which can lead to hypocalcemia and even osteoporosis.4 In addition, methylprednisolone can also cause a decrease in immunity in children, which can increase the probability of infection.