Acne refers to acne in medicine, and hard pimples on the cheeks indicate that acne on the face may develop into nodular acne, which is a severe form of acne. Clinically, it is mainly treated by systemic medication and topical medication. 1. Systemic drugs: (1) Isotretinoin: Oral isotretinoin can effectively reduce sebum secretion and regulate the abnormal keratinization of sebaceous gland ducts in hair follicles, thus improving the anaerobic environment of hair follicles and reducing the reproduction of Propionibacterium acnes. (2) Antibiotics: Oral antibiotics are also one of the effective methods for the treatment of moderate-to-severe acne. Minocycline and doxycycline are preferred, followed by macrolide antibiotics, such as azithromycin. (3) Glucocorticoid: For severe nodular acne, intradermal injection of glucocorticoid drugs can be used for treatment, such as the commonly used compound betamethasone and triamcinolone acetonide suspension. 2. Topical drug treatment: (1) Vitamin A acid drugs: topical application can play a role in reducing the follicle epithelial cell hyperkeratosis and the viscosity of the stratum corneum, which in turn reduces the formation of microcomedones and accelerates the discharge of acne. Commonly used drugs include adapalene and tazarotene. (2) Antibacterial drugs: such as the common benzoyl peroxide, which can play a role in killing Propionibacterium acnes and can also mildly dissolve acne, but is prone to irritation reactions, it is best to use in a small area; antibiotics such as erythromycin, clindamycin and so on, which can play a role in combating Propionibacterium acnes and anti-inflammatory effects. When the appearance of hard cheek acne, pay attention to the timely visit to the hospital, under the guidance of the doctor to carry out reasonable treatment, follow the doctor’s prescription medication.