Anti-islet cell antibodies of 0.08 are normal and can be seen in normal individuals, type 2 diabetes, and idiopathic type 1 diabetes. Anti-islet cell antibody is an organ-specific antibody, the antigen is the cytoplasmic or microsomal component of islet cells, which is a sign of immune damage to pancreatic islet β-cells, and positivity is most common in immune-mediated type 1 diabetes mellitus. Negative anti-islet cell antibodies can be seen in normal people, diabetic patients with negative islet cell antibodies, consider the possibility of type 2 diabetes mellitus, type 2 diabetes mellitus is not an autoimmune disease, and its occurrence is related to genetic, environmental and other factors. Patients with abnormal anti-islet cell antibodies should go to the hospital and be treated under the guidance of a doctor.