It is normal for ichthyol to hurt more and more when rubbing pustules, as the drug works on the pustules, and ichthyol can be discontinued after the pustules have broken down. The ichthyol is usually called ichthyol ointment, with mild irritation and anti-inflammatory, antiseptic and swelling effect, often used for external application in the local treatment of boils, during the use of the drug often produce local skin irritation, coated in the pustules, with the growth of the pustules, may be more and more pronounced pain until the pustules burst. During the use of ichthyol ointment, if the pain is intolerable, it is necessary to stop or switch to other drugs under the guidance of a medical professional. As ichthyol ointment is irritating, it should not be used on broken skin. Patients are advised to stop using it after the pustules have broken down, and avoid contact with the eyes and other mucous membranes, such as the mouth and nose. It is recommended that patients use ichthyol ointment before strictly under the guidance of a professional physician, not blindly self-medication, so as not to produce adverse reactions, delay the condition.