Numbness of the toes in diabetic patients is a more typical symptom of diabetic peripheral neuropathy, which is usually seen in patients with a longer history of diabetes and poor glycemic control in general. In terms of treatment, both oral hypoglycemic drugs and insulin therapy should be used to further control blood glucose. Nutritional drugs, such as Epalrestat or methylcobalamin tablets, should also be added. Drugs to improve circulation, such as pancreatic kininogenase, should also be added to improve the blood supply around the nerves, which is favorable to the recovery of the nerves. Through the above treatments, the symptoms of numbness in the toes of diabetic patients will be improved, but it is still difficult to achieve a complete cure, because the damage of all chronic complications in diabetic patients is irreversible, especially the damage of peripheral neuropathy.