Obese prediabetic patients who lose weight/increase physical activity or take metformin may not only reduce their progression to diabetes, but may also sufficiently reduce the risk of heart disease, says a study in the August 26, 2013 online issue of the Journal of Clinical Endocrinology and Metabolism. The study used two different methods, nuclear magnetic resonance (NMR) imaging and density gradient centrifugation (DGU), to determine which method produced “beneficial lipids” in reducing the development of atherosclerosis: weight loss/increased physical activity, metformin use or placebo use.