The preferred treatment option for left adrenal thickening depends on the specific disease. Left adrenal gland thickening can be seen in pheochromocytoma, primary aldosteronism, Cushing’s syndrome, adrenal tumors and so on. 1. Pheochromocytoma: it is adrenal medulla tumor, when adrenal medulla lesion occurs, it may cause adrenal gland thickening. Pheochromocytoma releases a large amount of catecholamines, which can cause persistent hypertension and metabolic disorder. Alpha receptor antagonist such as prazosin can be applied to make the blood pressure drop and reduce the burden on the heart after surgical treatment. 2. Primary aldosteronism: it is due to the tumor or occupational lesion in the adrenal cortex that causes the increase of aldosterone secretion, which is manifested as hypertension and hypokalemia. Surgery can be preferred as the first choice of treatment, and if the effect of surgery is poor, medication such as spironolactone can be used. 3. Cushing’s syndrome: it is an endocrine disease caused by long-term secretion of glucocorticoid hormone by adrenal cortex, surgical treatment is preferred. 4. Adrenal tumor: adrenal tumor belongs to occupying lesion, surgical treatment is preferred. All the above medications should be used under the guidance of doctors, avoid self-medication. If patients find that the left adrenal gland is enlarged, it is recommended to go to regular hospitals in time, improve the examination to clarify the cause of the disease, and then give targeted treatment or therapy under the guidance of the doctor.