Chills and fever can occur in many clinical conditions, such as pneumonia, acute appendicitis, acute cholecystitis, and acute pyelonephritis. If a patient has symptoms of chills and fever, it is recommended to actively seek medical attention, improve relevant examinations, and clarify the diagnosis. The treatment of different diseases is different: 1. Chills and fever caused by severe pneumonia require assessment of the causative organism and active anti-infective treatment according to the causative organism. 2. If the patient has chills and fever due to acute pyelonephritis, anti-infective treatment is required, using If the patient has chills and fever due to acute appendicitis or acute cholecystitis, surgical treatment can be considered.